Guiding principles for natural product drug discovery
نویسندگان
چکیده
منابع مشابه
Guiding principles for natural product drug discovery.
Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...
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While natural products or their derivatives and mimics have contributed around 50% of current drugs, there has been no approach allowing front-loading of chemical space compliant with lead- and drug-like properties. The importance of physicochemical properties of molecules in the development of orally bioavailable drugs has been recognized. Classical natural product drug discovery has only been...
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The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysin...
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1 Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina 2Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain 3 Universidade do Vale do Itajaı́, Núcleo De Investigações Quı́mico-Farmacêuticas (NIQFAR), CCS, Brazil 4Department of Chemistry, University of Alabama in Huntsv...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2012
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.12.55